Preparation and dissolution characteristics of solid dispersion of ginsenoside Rg_3
- VernacularTitle:人参皂苷Rg_3固体分散体的制备与体外特性研究
- Author:
Kaoxiang SUN
;
Huifang LV
;
Rongcai LIANG
;
Aiping WANG
;
Hongjie MU
- Publication Type:Journal Article
- Keywords:
ginsenoside Rg3;
solid dispersion;
dissolution in vitro;
solubility
- From:
Chinese Traditional and Herbal Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare the solid dispersion of ginsenoside Rg3 with different carriers and measure their solubility and dissolution characterisitics. Methods The solid dispersion of ginsenoside Rg3 was prepared by the melted and dissolved methods with Poloxamer 188(F68), PVP k29/32, and PEG 6000 as carriers, respectively. The equilibrium solubility and dissolution characteristics of the solid dispersion in vitro were measured by HPLC. The existing state of ginsenoside Rg3 in the solid dispersion was identified by the differential scanning calorimetery. Results The ginsenoside Rg3 was completely dispersed in carrier and formed a mixture with carriers. The solubility and dissolution rates of all solid dispersion were increased obviously. Conclusion The solid dispersion of ginsenoside Rg3 with Poloxamer 188 as carriers is better on improving dissolution and solubility than those with PVP and PEG 6000 as carriers.
