Absorption mechanism of paeoniflorin across Caco-2 monolayer model
- VernacularTitle:芍药苷在Caco-2细胞模型中吸收机制的研究
- Author:
Li SONG
;
Ning ZHANG
;
Desheng XU
- Publication Type:Journal Article
- Keywords:
paeoniflorin;
Caco-2 cell model;
intestinal absorption;
transport
- From:
Chinese Traditional and Herbal Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the absorption mechanism of paeoniflorin across Caco-2 monolayer model. Methods Depending on the Caco-2 cell monolayers drug transport model to study the double transport mechanism of paeoniflorin. To explore the effect of paeoniflorin absorption by time and drug concentration, the drug concentration was determined through the use of HPLC instrument and the Papp was calcalatad. Results In the Caco-2 monolayer model, the transport of paeoniflorin form Apical (AP) to Basolateral (BL) is similar to the transport form BL to AP. Conclusion The main mechanism of the paeoniflorin intestinal absorption in the Caco-2 monolayer model is passive transference.
