Comprehensive evaluation of ophiopogonin enteric microsphere
- VernacularTitle:麦冬皂苷肠溶微球综合评价方法研究
- Author:
Haiying HE
;
Yi FENG
;
Desheng XU
;
Lan SHEN
- Publication Type:Journal Article
- Keywords:
ophiopogonin;
spray-drying;
enteric microsphere;
synthetic evaluating method
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To prepare ophiopogonin enteric microsphere and to carry out the comprehensive evaluation.METHODS:The microsphere was prepared by spray-drying technology,it was evaluated by common index、 enteric index and physical index.RESULTS:Yield was(81.7? 2.1)%,embedding ratio was(86.55? 0.86)%,drug loading was(23.1? 0.2)%.The drug released degree in artificial gastric juice within 2 hours was(9.18? 0.08)%.The drug released rate in artificial intestinal juice within 45 minutes was(73.79? 0.29)%.The equilibrium moisture content decreased from 12.9% to 5.8%.CONCLUSION:An comprehensive evaluation was established.
