In situ rat intestinal absorption of hawthorn leaves flavonoids
- VernacularTitle:山楂叶总黄酮的在体肠吸收研究
- Author:
Yingai XU
;
Guorong FAN
;
Shen GAO
;
Zhanying HONG
- Publication Type:Journal Article
- Keywords:
hawthorn leaves flavonoids;
rhamnosylvitexin;
intestinal absorption;
in situ single-pass perfusion;
P-glycoprotein
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).But the P_ eff values were significantly increased in the presence of P-glycoportein(P-gp)inhibitor,verapamil or digoxin.CONCLUSION:Rhamnosylvitexin can be classified into high penetrating drug.Passive diffusion dominates the absorptive transport behavior of rhamnosylvitexin in HLF.There is not a preferential absorption zone in the intestine for rhamnosylvitexin.The absorption and secretion of rhamnosylvitexin in HLF are mediated by the efflux transport system,P-gp.
