Pharmacokinetics of hydroxyl-?-dextrin sodium new houttuyfonate injection in beagle dogs
- VernacularTitle:注射用羟丙基?-环糊精-新鱼腥草素钠冻干粉针Beagle犬体内的药代动力学
- Author:
Guihai LI
;
Fengqin LIU
;
Fujun SUN
;
Hongjian LI
;
Tianyun LIU
- Publication Type:Journal Article
- Keywords:
sodium new houttuyfonate;
HPLC;
hydroxyl-?-dextrin;
pharmacokinetics
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To establish the method of determining sodium new houttuyfonate in plasma and study its pharmacokinetics in beagle dogs.METHODS:The HPLC was employed with chromatographic conditions,such as octa-silicane bond silica gel column(250 mm?4.6 mm,5 ?m)as analytical column,methanol-water-ammonium hydroxide with 4 butyls(70 ∶30 ∶0.3)as mobile phase and at the flow-rate of 1.0 mL/min.The UV detection was set at 286 nm.The pharmacokinetic parameters were calculated by DAS(ver 1.0)program and compared by statistic analysis.RESULTS:The calibration curve was linear in blood plasma over the concentration range of 0.128～25.575 mg/L(r= 0.999 2),good precision and high recoveries.The parameters were T_ max= 5.0 min,C_ max= 4.982 mg/L,T_ 1/2=8.67 min.CONCLUSION:The analytical method established in this study is sensitive and exact,and can be used to measure the pharmacokinetics of sodium new houttuyfonate in beagle dog.The sodium new houttuyfonate can metabolize quickly following intravenous injection.
