Expression of GFAP in adult rats hippocampus of onset subclinical seizures following hypoxic brain damage
- VernacularTitle:成年大鼠缺氧性脑损伤后亚临床发作及胶质原纤维酸性蛋白的表达
- Author:
Xiu CHEN
- Publication Type:Journal Article
- Keywords:
Hypoxic brain injury;
Subclinical seizure;
GFAP;
Neuronal loss
- From:
Journal of Chongqing Medical University
2007;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mechanism of early onset subclinical seizures following hypoxic brain injury. Methods:SD male adult rats were assigned randomly to control rats and rats exposed to global hypoxia by 8% oxygen nitrogen atmosphere. According to electroencephalogram recording seizure discharge,hypoxie rats were divided into subclinical seizures group and non-subclinical seizures group,then the changes in neuropathology and the expression of GFAP in cortex and hippocampus of rat brain were studied by Nissle-staining immunohisochemistry and western-blot. Results:Subclinical seizures occurred in 19.67% rats following hypoxia. Compared with non-subclinical seizure group,neuronal loss of hippocampal CA1 and CA3 region as wel as temporal cortex were distinct in subclinical seizure group(P
