Study on the Regulatory Effect of Xinchuan Capsules on the Excessive Aactivation of Neuroendocrine of Dogs with Experimental Heart Failure
- VernacularTitle:心喘胶囊对犬实验性心力衰竭时神经内分泌过度激活的调节作用研究
- Author:
Zhixu YANG
;
Jie LI
;
Xiaohong SHANG
- Publication Type:Journal Article
- Keywords:
Xinchuan capsules;
heart failure;
neuroendocrine;
dog
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the regulatory effect of Xinchuan capsules on the excessive activation of neuroendocrine with heart failure.Methods The heart failure animal model was built up using dogs by intravenous pumping of sodium pentobarbital.Water extract of Xinchuan capsules was given through duodenum.Indicators relating to the excessive activation of neuroendocrine changes of each group were observed.Results Xinchuan capsules could significantly increase the density of beta receptors of failure myocardial cells and lower the level of plasma norepinephrine and epinephrine,and remarkbly decrease the activity of plasma angiotensin converting enzyme.This played the similar role as the positive control drug metoprolol plus captopril.Conclusion Xinchuan capsules have the regulatory effect on the excessive activation of neuroendocrine with heart failure.TCM treatment for heart failure should not only target the functional disorder of the heart dominating blood circulation and vessels,but also the functional disorder of the heart stores the spirit,that is uneasy mental state.
