Effects of Bushenxingnao Prescription on Cerebral Neurocyte Apoptosis of Experimental Vascular Dementia Rats
- VernacularTitle:补肾醒脑方对实验性血管性痴呆大鼠脑神经细胞凋亡的影响
- Author:
Pan ZHENG
;
Yinman FENG
;
Hong ZHENG
- Publication Type:Journal Article
- Keywords:
Bushenxingnao prescription;
vascular dementia;
situ nick-end labeling;
apoptosis;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pathology mechanism of vascular dementia(VD)rats and study the effect of Bushenxingnao(BSXN)prescription on cerebral neurocyte apoptosis.Method Experimental VD model rats were caused by clipping two side of total artery in neck repeatedly and to examine cerebral neurocyte apoptosis with TUNEL.Results Both the high and low dose BSXN abated excitatory toxic infury and inhibit neurocyte apoptosis after ischemia-refusion.Conclusion BSXN prescription can repress cerebral neurocyte apoptosis,to abate its excitatory nerotoxicity,to protect cerebral neurocyte,which may be one of the mechanisms of to treating the lesion.
