Effects of Total Rhizoma Panacis Japonica Saponins on Nitric Oxide Synthase of Hippocampus Region in the Mouse Repetitious Cerebral Ischemia Reperfusion and the Rat Focal Cerebral Ischemia
- VernacularTitle:竹节参总皂苷对脑缺血再灌注模型海马组织一氧化氮合酶的影响
- Author:
Hui ZHAO
;
Haiyan ZOU
;
Meng XU
- Publication Type:Journal Article
- Keywords:
total thizoma panacis japonica saponins;
cerebral ischemia;
nitric oxide synthase
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of protective effects of total rhizoma panacis japonica saponins(tRPJS)on the cerebral ischemia injury.Methods The middle cerebral artery occlusion model (MCAO)in rats and cerebral ischemia-reperfusion models in mice were used to investigate the influence of tRPJS on the nitric oxide synthase(NOS)and inducible nitric oxide synthase(iNOS)activity in hippocampus region.Results tRPJS significantly decreased the contents of NOS and iNOS in hippocampus region of MCAO rat and cerebral ischemia reinfusion mouse.Conclusion tRPJS has significantly protective effects by decreasing NOS and iNOS.
