Effect of Paeonol on PGI2,TXA2,ET and NO in Diabetic Rats
- VernacularTitle:丹皮酚对糖尿病大鼠前列环素、血栓素A_2、内皮素、一氧化氮的影响
- Author:
Cunyun MIN
;
Heqiang LIU
;
Feng ZHAN
- Publication Type:Journal Article
- Keywords:
Paeonol;
diabetes mellitus;
vessel endothelial cells;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objetive To study the effect of Paeonol on PGI,TXA2,ET and NO in diabetic rats.Methods Streptozocin was used in dosage of 60 mg/kg on rats to make diabetic animal model.Defferent dosages of Paeonol were used on diabetic animal models.6-Keto-PGF1?,TXB2,ET and NO were tested after 30 days. Results Compared to the control group,6-Keto-PGF1?(pg/mL)of Paeonol groups increased from 89.75? 2.75,89.97?7.28,89.97?11.36 to 120.03?13.85,108.34?11.25,105.32?8.85 respectively;TXB2 (pg/mL)decreased from 157.64?10.36,156.64?11.35,153.33?19.40 to 124.46?18.67,136.40?18.15, 138.40?22.20 respectively;ET(pg/mL)decreased from 181.68?5.10,181.27?4.76,181.04?4.19 to 140.55?3.01,150.51?2.22,161.02?3.76.The change of 6-Keto-PGF1?,TXB2 and ET was related to the dosage of Paeonol.NO has no significant change.Conclusions Paeonol can decrease the ET and TXB2 in diabetic rats,and increase 6-Keto-PGF1?in diabetic rats.
