Protection of Polysaccharide GEP-2 from Gastrodia elata on Carbon Tetrachloride and Alcoholic Liver Injury in Mice
- VernacularTitle:天麻多糖-2对小鼠四氯化碳肝损伤和酒精肝损伤的保护作用
- Author:
Dekun HU
;
Yeshou SHEN
- Publication Type:Journal Article
- Keywords:
Gastrodia elata Polysaccharide;
mice;
carbon tetrachloride;
alcoholic liver injury
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protection effect of Polysaccharide GEP-2 from Gastrodia elata on carbon tetrachloride(CCl4)and alcoholic liver injury in mice.Methods CCl4 and alcohol were adopted to establish CCl4 and alcoholic liver injury model in mice respectively.Colorimetric method was used to assay the content of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST),and the content of triglyceride(TG)in alcoholic liver injury,the activity of superoxide dismutase(SOD)and malondiadehyde(MDA)consistent of liver homogenate in mice,and observe liver tissue pathological section.Results Polysaccharide GEP-2 from Gastrodia elata(25,50,100 mg/kg)administration obviously reduced the high level of ALT and AST in serum and the content of TG in alcoholic liver injury,inhibit the high level of MDA and increase the low activity of SOD in liver homogenate.Patholory inspection result indicated that Polysaccharide GEP-2 from Gastrodia elata exert notable influence on CCl4 and alcoholic liver injury in mice.Conclusion Polysaccharide GEP-2 from Gastrodia elata has apparently protective effects on CCl4 and alcoholic induced liver injury in mice.
