Effect of Tongbiding Injection on Expression of N-methyl-D-aspartate Receptor 1 mRNA in the Spinal Cord of Chronic Constriction Injury Rats
- VernacularTitle:痛必定注射液对坐骨神经结扎性慢性损伤模型大鼠脊髓NR1 mRNA表达的影响
- Author:
Zhongnan WANG
- Publication Type:Journal Article
- Keywords:
Tongbiding injection;
NR1 mRNA;
RT-PCR;
animal model
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Tongbiding injection on expression of N-methyl-D-aspartate (NMDA)receptor 1 mRNA in the spinal cord of chronic constriction injury(CCI)rats.Methods Thirty male Spragru-Dawley rats were randomly divided into control group(group A),CCI group(group B)and Tongbiding group(group C),ten rat for eah group.The changes in NR1 mRNA expression in the spinal cord was detected by reverse transcription-polymerase chain reaction(RT-PCR)techniques.Results The expression of NR1 mRNA in the spinal cord was minimal in control group,CCI induced significant increase in the expression of NR1 mRNA in the spinal cord and Tongbiding significantly inhibited the increase in NR1 mRNA expression.There was significant difference between CCI and Tongbiding group(P
