Effect of Nourishing Qi,Activating Blood Circulation and Dispersing Phlegm Recipe on the Pathology of Chronic Obstructive Pulmonary Disease Rat Models
- VernacularTitle:益气活血化痰方对慢性阻塞性肺疾病模型大鼠肺组织病理学的影响
- Author:
Cuiling FENG
;
Yan JIN
;
Hongli WU
- Publication Type:Journal Article
- Keywords:
nourishing Qi and activating blood circulation and dispersing phlegm recipe;
chronic obstructive pulmonary disease;
animal model
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish chronic obstructive pulmonary disease(COPD)rat models,and to study the intervention of the formula of nourishing Qi,activating blood circulation and dispersing phlegm recipe on the morphology.Method To establish rat COPD models by intratracheal instillation of lipopolysaccharide and exposure to cigarette smoke.To instill intervention drug daily either the formula of nourishing Qi,activating blood circulation and dispersing phlegm recipe or the roxithromythin,starting on the 20th,30th and 40th day of the experiment respectively(the groups was named h 20,h 30,h 40,r 20, r 30 and r 40 for short),and to observe the effect on the morphology by means of collagen staining and image analyzer.Results The pathological changes and lung function in the model group were accorded with the human COPD.In drug intervention groups,airway inflammation and epithelial proliferation were alleviated to different degree compared to the model group.In model group,the collagen deposition was increased predominant type I collagen compared to the health comtrol group,and the deposition in the drug intervention groups were decreased compared to the model group,according to the Sirius redpolarizing microscopy morphometry method.The thickness of the airway wall in the model group was significantly increased compared to the health control group(P
