Effect of Invigorating Spleen,Eliminating Stasis,Heat-Clearing Drugs on the Quality of Ulcer Healing and Expression of EGFR mRNA in the Rat Model of Gastric Ulcer
- VernacularTitle:健脾化瘀清热药对大鼠胃溃疡愈合质量及其表皮生长因子受体mRNA表达的影响
- Author:
Yongfeng ZHANG
;
Zhengzhi WU
;
Xiuqin JIA
- Publication Type:Journal Article
- Keywords:
gastric ulcer;
invigorating spleen,eliminating stasis,heat-clearing drugs;
epidermal growth factor;
quality of ulcer healing;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and mechanism of invigorating spleen,eliminating stasis, heat-clearing drugs(milk veteh,root of red rooted salvia,Chinese goldthread)on quality of ulcer healing (QOUH).Methods The rat models of chronic gastric ulcer was induced by acetic acid,the effects of QOUH of milk veteh,root of red rooted salvia and Chinese goldthread on the model of gastric Ulcer were observed, the expression of EGFR mRNA of mucosa were measured by in situ hybridization.Results Milk veteh,root of red rooted salvia and Chinese goldthread could improve the injury of gastric mucosa.Milk veteh,root of red rooted salvia increased the expression of EGFR mRNA in the tissue around peptic ulcer(PU). Conclusion Invigorating spleen,eliminating stasis,heat-clearing drugs can improve QOUH,it is one of possible mechanisms that the drugs increased the expression of EGFR mRNA in the tissue around PU.
