Protection of ethanol extract and fractions from Polygonatum odoratum on renal lesion in diabetic rats
- VernacularTitle:玉竹乙醇提取物和分离部位对糖尿病大鼠肾脏的保护作用
- Author:
Haibo SHI
;
Yanbo MIAO
;
Liping WANG
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
Polygonatum odoratum (Mill.) Druce;
diabetic nephropathy (DN);
advanced glycation end products (AGEs)
- From:
Chinese Traditional and Herbal Drugs
1994;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the protective effects of the ethanol extract and fractions from Polygonatum odoratum on renal lesion in diabetic rats. Methods An experimental diabetic rat model was successfully induced by one ip injection of streptozotocin (STZ) at a dose of 60 mg/kg. Diabetic rats were ig administrated the ethanol extract or fractions for 80 d. Serum levels of creatinine (Cr), urea (Ur), glycosylation hemoglobin (GHb), renal advanced glycation end products (AGEs), and urinary albumin (UAL) excretion rate were determined by biochemical methods. Glomerular volume and renal pathological changes were observed by optic microscope. Results Treatments with the ethanol extract and chloroform fraction decreased the levels of GHb and UAL excretion rate, and inhibited renal AGEs formation and renal pathological changes in STZ-induced diabetic rats. Conclusion The ethanol extract and chloroform fraction have protective effects on renal lesion in diabetic rats, which might be related to inhibiting AGEs formation.
