Effects of Loganin on the Proliferation and Differentiation of Rat Preadipocyte
- VernacularTitle:马钱苷对大鼠前脂肪细胞增殖与分化的影响
- Author:
Bing DAI
;
Zizeng XIAO
;
Lei LIU
;
Wang LENG
;
Shuanghua ZOU
- Publication Type:Journal Article
- Keywords:
Loganin;
Rat preadipocytes;
Cell proliferation;
Cell differentiation
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of 1oganin on proliferation and differentiation of rat preadipocytes. Methods Rat preadipocytes were cultured. The proliferation of rat preadipoeytes was detected by MTT method. The expression of GPDH during the preadipoeytes differentiation was determined by using enzyme tissue chemical way, and the accumulation of cellular lipid was determined by Oil Red O staining. Results Loganin at the concentrations of 8, 16, 32 ? mol/L stimulated rat preadipocyte proliferation, inhibited GPDH increase and lipid accumulation during differentiation in a concentration-dependent manner. Conclusion Loganin can stimulate rat preadipocyte proliferation, inhibite rat preadipocyte differentiation.
