Anti-depression Effect of Shugan Hewei Granules on Mice with Behavioral Despair
- VernacularTitle:疏肝和胃颗粒对行为绝望小鼠的抗抑郁作用
- Author:
Shuwen MA
;
Tianqin XIONG
;
Shili WEI
;
Qian GUO
;
Xuejun ZHAO
- Publication Type:Journal Article
- Keywords:
SHUGAN HEWEI GRANULES/pharmacology;
DEPRESSION/TCD therapy;
DISEASE MODELS,ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the anti-depression effect of Shugan Hewei Granules(SHG) on mice with behavioral despair.【Methods】Kunming mice were randomized into 5 groups: model group,low-,moderate-and high-dose SHG groups(in the dosages of 0.25,0.5 and 1.0 g?kg-1?d-1respectively) and chloropromazine(CP) group.Tail suspension test and forced swimming test were used to investigate immobility time of mice.【Results】Moderate-and high-dose SHG shortened the immobility time obviously during tail suspension test and forced swimming test(P
