Effect of Jianzhong Yuyang Tablets on Prostaglandin E_2 Content in Gastric Mucosa of Rats with Gastrointestinal Injury Induced by Indomethacin
- VernacularTitle:健中愈疡片对消炎痛大鼠胃粘膜前列腺素E_2含量的影响
- Author:
Weihong KUANG
;
Tongguang YANG
- Publication Type:Journal Article
- Keywords:
JIANZHONG YUYANG TABLETS/pharmacology;
GASTRIC MUCOSA INJURY/TCD therapy;
PROSTAGLANDINS;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the effect of Jianzhong Yuyang Tablets(JYT) on prostaglandin E2(PGE2) content in gastric mucosa of rats with gastrointestinal injury induced by indomethacin.【Methods】One hundred and seven SD rats were randomized into 7 groups: blank control group,model group,famotidine(7.14 mg?kg-1?d-1)group,two Radix Codonopsis(RC,0.71 and 2.84 g?kg-1?d-1 respectively) groups,two JYT(0.27 and 1.08 g?kg-1?d-1 respectively) groups.Except the blank control group,the rats in other groups were given subcutaneous injection of indomethacin 20 mg/kg to induce gastrointestinal injury.PGE2 content in gastric mucosa of rats were detected with radioimmunoassay 7 hours and 7 days after modeling respectively.【Results】PGE2 content in gastric mucosa of model rats was lower than that in the blank control group 7 hours and 7 days after modeling(P
