Effect of Chinese Herbal Medicine Compatibility on Aristolochic Acid Content in Caulis Aristolochiae Manshuriensis
- VernacularTitle:不同中药配伍对关木通毒性成分马兜铃酸A含量的影响
- Author:
Shijian QUAN
;
Jie DING
;
Hongdan WANG
- Publication Type:Journal Article
- Keywords:
CAULIS ARISTOLOCHIAE MANSHURIENSIS/chemistry;
LONGDAN XIEGAN DECOCTION;
ARISTOLOCHIC ACID/analysis;
COMPATIBILITY(TCD);
CHROMATOGRAPHY,HIGH PRESSURE LIQUID
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To compare aristolochic acid(AA)content in Caulis Aristolochiae Manshuriensis(CAM)and in the separated prescriptions of Longdan Xiegan Decoction(LXD),and to explore the effect of Chinese herbal medicine compatibility on AA content.【Methods】According to the herbs percentage compared to LXD,the herbs samples were named after: CAM group,LXD group,CAM group with heat-clearing herbs,CAM group with yin-nourishing herbs,CAM group with herbs for promoting urination,CAM group with Radix Glycyrrhizae,and LXD group with CAM removed.The AA content was determined by reverse phase HPLC.The chromatographic conditions were as follows: C18 Diamonsiltm analytical column,gradient eluted with a mixture of methyl alcohol,water and acetic acid(volume proportion as 74:24:1),and detection wavelength at 315 nm.【Results】AA content was the lowest in LXD group,and was lower in CAM group with yin-nourishing herbs than that in CAM group.【Conclusion】Subjecting to the theory of Chinese herbal medicine compatibility,it is feasible to reduce the CAM toxicity by composing a prescription with proper proportion of herbs.
