Establishment and identification of hu-PBL-SCID mice model of human renal cell carcinoma
- VernacularTitle:人免疫重建荷人肾癌SCID小鼠模型的建立及其鉴定
- Author:
Shihui LIU
- Publication Type:Journal Article
- Keywords:
Renal cell carcinoma;
SCID mice;
Immune reconstructon;
Animal model.
- From:
Journal of Chongqing Medical University
2007;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the feasibility of establishing a human renal cell carcinoma model in human peripheral blood lymphocyte-engrafted to severe combined immunodeficient(hu-PBL-SCID)mice.Methods:The biological and immunological features of mice were evaluated after intra-peritoneal injection of human peripheral blood lymphocytes(PBL)and subcutaneous implantation of human renal cell carcinoma cells(RCCCs).Results:(1)Subcutaneous tumors developed in all the mice given human PBL and RCCCs.The latency period was significantly prolonged,and the tumor size was markedly depressed,as compared with the mice given RCCCs(P
