Expressions of MMP-2,MMP-3,MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance
- VernacularTitle:CD147与基质金属蛋白酶-2,3,9在卵巢癌中的表达及临床病理意义
- Author:
Jingxian WU
- Publication Type:Journal Article
- Keywords:
CD147;
Matrix metalloproteinase-9;
Matrix metalloproteinase-2;
Matrix metalloproteinase-3;
Ovarian cancer;
Immuno-histochemistry
- From:
Journal of Chongqing Medical University
2007;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of MMP-2,MMP-3,MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance.Methods:Immunohisto chemical S-P method was performed to detect the expressions of MMP-2,MMP-3,MMP-9,CD147 in 40 malignant and 9 benign ovarian tumors.Result:The expression rates of MMP-2,MMP-3,MMP-9 and CD147 in ovarian cancer were 92.5%,100%,100% and 95%,respectively.The expressions of MMP-2,MMP-3,MMP-9 and CD147 in ovarian cancer were related with clinical stage and pathological garade(P0.05).There were positive correlations between the expressions of CD147 and MMP-2,MMP-3,MMP-9(r=0.802,0.786,0.914)in ovarian cancer.Conclusion:Expressions of CD147,MMP-2,MMP-3 and MMP-9 have relevance to clinical stages and pathological grades in ovarian cancer,and overexpression of CD147 may induce the secretion of MMP-2,MMP-3,MMP-9.
