Influence of Invigorating Spleen and Restoring Virility to the SS Level and SSR1 Gene Expression in Brain of Spleen Insufficiency Model of Rat
- VernacularTitle:健脾与补肾对脾虚模型大鼠脑内生长抑素水平和受体基因表达的影响
- Author:
Huinan QIAN
;
Le WANG
;
Xueqin HU
- Publication Type:Journal Article
- Keywords:
invigorating spleen and restoring virility;
SS;
SSR1 mRNA gene expression;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare on the influence of invigorating spleen and restoring virility to the SS level and SSR1 gene expression in brain. Method The spleen insufficiency model of rat was established by adopting bitter decline diarrhea, wild eating and overworking. SS level and SSR1 gene expression change of hypothalamus ventral kernel, hippocampi CA1 area and forehead corte were detected by immunohistochemistry and in situ hybridization techniques. Result In the model group, the immunoreaction masculine substance of SS and SSR1 mRNA, hypothalamus ventral kernel, hippocampi CA1 area and forehead cortex decreased obviously. The immunoreaction masculine substance of SS and SSR1 mRNA on above mentioned parts in the group of invigorating spleen and restoring virility increased distinctly. Conclusion In the model group, the SS level and SSR1 gene expression in brain to promoting study memory ability changed. Invigorating spleen and restoring virility may affect study memory ability by regulating the SS level and SSR1 gene expression.
