Study on the Mechanism of Kangnaoling Capsule Resisting Free Radical Injury of Vascular Dementia Rat
- VernacularTitle:康脑灵胶囊抗痴呆大鼠自由基损伤的作用机制研究
- Author:
Xuming JI
;
Fang WANG
;
Guiju ZHANG
- Publication Type:Journal Article
- Keywords:
Kangnaoling capsule;
vascular dementia;
free radical injury;
Bcl-2;
caspase-3;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protection of Kangnaoling capsule to free radical injury and influence on the expression of caspase-3 and Bcl-2 in neuron of VD rat. Methods VD rat model was duplicated. Using spectrophotometry to detect contents of SOD, MDA and NO, spectro-fluorimeter to detect the expression of caspase-3, spectrophotometric method to detect the expression of Bcl-2 after traditional Chinese medicine interference. Results Kangnaoling capsule can markedly reduce the contents of MDA, raise contents of SOD and NO, degrade the expression of caspase-3, enhance the expression of Bcl-2. Conclusions Kangnaoling capsule can markedly protect VD rat from free radical injury, which probably correlated with increasing expression of Bcl-2, decreasing expression of caspase-3.
