Influence of the Coumarins from Radix Angelicae Pubescentis on the Hypnotic Effects of Pentobarbital Sodium and Barbital Sodium in Mice
- VernacularTitle:独活香豆素组分对戊巴比妥钠及巴比妥钠催眠作用的影响
- Author:
Decai WANG
;
Tongde LI
;
Xiaoyan XU
- Publication Type:Journal Article
- Keywords:
coumarins from Radix Angelicae Pubescentis;
pentobarbital sodium;
barbital sodium;
hypnotic effect;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of the coumarins from Radix Angelicae pubescentis (TCA) on the hypnotic effects of pentobarbital sodium and barbital sodium. Methods Mice were randomly divided into solvent (5% Tween-80, 20 mL/kg), chloromycetin (25 mg/kg) and TCA (50, 100 mg/kg) groups, which were administered orally with equivalent volume. One hour later, all the animals were given pentobarbital sodium (40 mg/kg, ip) or barbital sodium (200 mg/kg, ip), and then the latent period and duration of hypnosis were observed. Results Hypnotic duration of pentobarbital sodium was prolonged by 249.8%, 171.1% and 78.7% in chloromycetin and two TCA groups respectively (P
