Dispersing form of puerarin solid dispersion and its evaluation in vitro
- VernacularTitle:葛根素固体分散体的分散状态及其体外评价
- Author:
Shubin WANG
;
Lanzhi HUANG
- Publication Type:Journal Article
- Keywords:
puerarin;
sustained-release solid dispersion;
X-ray diffraction;
differential scanning calorimetry (DSC)
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to observe the dispersing form, the sustained release solid dispersion was prepared. Methods Sustained-release solid dispersion was prepared by taking ethyl cellulose as carrier. And the X-ray diffraction, differential scanning calotimetery (DSC) were used to evaluate the dispersing form of puerarin in the preparation and to study the solubility in vitro. Results The X-ray diffraction experiment showed that the puerarin was existed in molecuar and minicrystal form. DSC Experiment showed that there is no puerarin crystal in the solid dispersion. The test for stripping showed that thare was a better releasing results in the sustained-release capsula. Conclusion The sustained-release solid dispersion can disperse the puerarin highly to increase its bioavailability. The prepared capsula has a marked sustained-release effect.
