Dynamic effect of Huanglian Jiedu Tang on Nimodipine disposition in rat brain
- VernacularTitle:黄连解毒汤对尼莫地平在大鼠脑内处置动力学的影响
- Author:
Dongmei ZHANG
;
Zhenwei HE
;
Yang LI
;
Xiaodong LIU
- Publication Type:Journal Article
- Keywords:
Huanglian Jiedu Tang (HLJDT);
Nimodipine;
baicalin;
brain microvessel endothelial cells (rBMEC)
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
10 ng/mL). But berberine (10 ng/mL) showed no effect on the uptake of Nimodipine. Conclusion The experimental findings indicate that HLJDT pretreatment might alter the pharmacokinetic behavior of Nimodipine both in plasma and brain tissue. The change of pharmacokinetic behavior of Nimodipine in brain tissue might partly result from the effect of baicalin in HLJDT.
