Preparation and percutaneous absorption in vitro of Ruanganxiaoshui Cataplasma
- VernacularTitle:软肝消水巴布剂的研制及其体外透皮研究
- Author:
Ping ZHANG
;
Qiang FU
- Publication Type:Journal Article
- Keywords:
Ruanganxiaoshui Cataplasma;
ginsenoside Rg_1;
accumulative dissolution rate in vitro;
percutaneous absorption in vitro
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the prepartion of Ruanganxiaoshui Cataplasma and it's percutaneous absorption in vitro as well as dissolvability in vitro. METHODS: In the experiment,orthogonal test was used to optimize the preparation.Meanwhile,with the help of azole and propylene alcohol the percutaneous absorption of ginsenoside Rg_1 from the cataplasma carriers in vitro was determined by Franz's diffusion cell and HPLC,as well as dissolution rate in vitro. RESULTS: The percutaneous absorption rate of ginsenoside Rg_1 through rat skin in vitro was 0.394 ?g/cm~2/h.And the dissolution process fitted to first order model. CONCLUSION: The Cataplasma carriers possess a good drug dissolution property.To add compound penetration enhancers is one of the effective methods for raising percutaneous absorption.
