Study on In-vivo Nasal Mucosa Absorption of Tetramethylpyrazine Phosphate Liposome in Rats
- VernacularTitle:磷酸川芎嗪脂质体大鼠在体鼻黏膜吸收研究
- Author:
Yilin YAN
;
Liling ZHOU
;
Yong YE
;
Quan AN
- Publication Type:Journal Article
- Keywords:
Tetramethylpyrazine phosphate(TMPP) liposome;
Nasal circulatory perfusion method;
Nasal mucosa absorption;
Absorption rate constant
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristic of in-vivo nasal mucosa absorption of tetramethylpyrazine phosphate(TMPP) liposome in rats. Methods Nasal circulatory perfusion method in rats was used to study the effects of different circulatory rates and TMPP concentrations on nasal mucosa absorption of TMPP liposome. Nasal mucosa absorption rate constants of TMPP liposomes and TMPP solutions at the same concentration were also compared. Results The absorption rate constant of TMPP liposomes was increased with the increase of circulatory rates at the range of 1.2～2.4 mL/min and with the increase of TMPP concentrations at the range of 0.245～0.98 mg/mL. Both the absorption rate constant and absorbed amount of TMPP for TMPP liposomes were higher than those for TMPP solutions at the same concentration. Conclusion The nasal mucosa absorption of TMPP liposome was complete as compared with that of TMPP solution.
