Inhibitory Effect of Acanthopanax Senticosus Saponin on the Expression of Vascular Endothelial Growth Factor in Human HepG_2 Cell Line
- VernacularTitle:刺五加皂苷对人肝癌细胞株血管内皮生长因子表达的抑制作用
- Author:
Jundong FENG
;
Daihua LIN
;
Xiqin LIU
;
Yaodong DAI
- Publication Type:Journal Article
- Keywords:
Acanthopanax senticosus spaponin;
HepG2;
Vascular endothelial growth factor
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Acanthopanax senticosus saponin (ASS)on the protein and mRNA expression of vascular endothelial growth factor (VEGF) in human HepG2. Methods HepG2 were incubated with ASS,the expression of VEGF was detected by ELISA assay,and the mRNA expression of VEGF was detected by RT-PCR assay. Results ASS (250,500 ?g/mL) decreased the expression of VEGF protein and VEGF mRNA (P
