Study on the Preparation of HP-?-cyclodextrin Inclusion of Volatile Oils in Anti-virus Oral Solution
- VernacularTitle:抗病毒口服液中挥发油羟丙基-?-环糊精包合物的制备研究
- Author:
Liming DENG
;
Huaqing LIN
;
Hong DENG
;
Hang CHEN
- Publication Type:Journal Article
- Keywords:
Anti-virus Oral Solution;
Volatile oils;
HP-?-cyclodextrin inclusion compound;
Orthogonal test
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the HP-?-cyclodextrin(HP-?-CD)inclusion process condition for volatile oils from Anti-virus Oral Solution. Methods The process conditions were screened by determining the inclusion rate of volatile oils and the yield of inclusion compound,and by comparing the inclusion effect of supersonic method,saturated water solution method and grinding method.The optimum condition was investigated by the orthogonal test. The inclusion compound was identified by TLC,differential scanning calorimetry(DSC) and ultraviolet spectrophotometry (UV). Results The optimum preparation conditions for inclusion were established as follows: the proportion of volatile oils and HP-?-cyclodextrin was 1 ∶12,the inclusion temperature was at 45 ℃and the inclusion time was 3 hours .The inclusion rate of volatile oils was 66.71 %,and the yield of inclusion compound was 90.07 %. Conclusion The complex prepared under the optimized condition is stable and has a highest inclusion rate.
