Determination of sildenafil citrate illegally mixed into traditional Chinese medicinal preparation by ultra performance liquid chromatography-tandem mass spectrometry
- VernacularTitle:超高效液相色谱-串联质谱法测定中成药中非法添加枸橼酸西地那非的研究
- Author:
Cuiying ZHANG
;
Zhenguo LI
;
Jinling XU
;
Naiqiang LIU
- Publication Type:Journal Article
- Keywords:
ultra performance liquid chromatography(UPLC);
tandem mass spectrometry(MS/MS);
sildenafil citrate
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish a quick,accurate,sensitive method for analysing sildenafil citrate illegally added into traditional Chinese medicinal preparation. METHODS: The ultra performance liquid chromatography-quadrupole mass spectrometry method was used.Electrospay ionization(ESI) source was applied and operated in the positive and negative ion mode.The compound of sildenafil citrate illegally added into traditional Chinese medicinal preparations were identified according to the spectrum,chromatographic behavior and mass spectral data by comparison with those of reference substance. RESULTS: Sildenafil citrate was found in two formulations of three. CONCLUSION: The method is selective and sensitive and can be used to detect the sildenafil citrate illegally added into traditional Chinese medicinal preparations.
