Protective Effect of Phyllanthus Compound Ⅱon Experimental Hepatic Damage in Mice
- VernacularTitle:叶下珠复方Ⅱ号对小鼠实验性肝损伤的保护作用
- Author:
Xiaohui LI
;
Gang LI
;
Changqing LI
;
Junfang SU
- Publication Type:Journal Article
- Keywords:
PHYLLANTHUS COMPOUND Ⅱ/pharmacology;
HEPATIC DAMAGE/TCD therapy;
LIVER/pathology;
DISEASE MODELS,ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the protective effect of Phyllanthus Compound Ⅱ(PCⅡ) on experimental hepatic damage in mice.【Methods】Sixty NIH mice were randomized into 5 groups: normal control group,model group,high-,moderate-and low-dose PCⅡ(110,55,and 27.5 g/kg respectively) groups,bifendate(150 mg/kg) group.Mice models of acute hepatic damage were induced with concanavalin A(Con A) and D-galactosamine(D-GalN)respectively.Serum levels of alanine transferase(ALT) and aspartate transferase(AST),and superoxide dismustase(SOD) activity were examined.The pathological changes of hepatic tissue were also observed.【Results】 PCⅡmarkedly decreased serum ALT and AST levels,and decreased hepatic SOD activity(P0.05 compared with bifendate group).The hepatic pathological changes were improved in PCⅡ groups.【Conclusion】PCⅡ exerts a better protective effect on mice hepatic damage induced by Con A and D-GalN,and its protective mechanism may be related with the inhibition of lipoperoxidation damage.
