Effect of Zhuyun Prescription Ⅲ on TCR??T Cells in Luteal Insufficiency Abortion Rats with Kidney Deficiency
- VernacularTitle:助孕3号方对肾虚黄体不健流产大鼠TCR??T细胞的影响
- Author:
Ying ZHOU
;
Songping LUO
;
Limian XU
;
Ying YAN
;
Hongyan ZHAO
- Publication Type:Journal Article
- Keywords:
ZHUYUN PRESCRIPTION Ⅲ/pharmacology;
ABORTION,SPONTANEOUS/TCD therapy;
ABORTION,SPONTANEOUS/immunology;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the effect of Zhuyun Prescription Ⅲ(ZPⅢ),which is composed of kidney-tonifying and spleen-strengthening herbal medicine,on T lymphocyte antigen recognition receptors(TCR?&T) in luteal insufficiency abortion rats with deficiency of kidney.【Methods】Forty SD rats were equally randomized into 5 groups: blank control group,model group,high-and low-dose ZPⅢ groups(in the doses of 7.08 and 3.54 g?kg-1?d-1,respectively) and allylestrenol tablets(1.5 mg?kg-1?d-1) group.Luteal insufficiency abortion rats model with deficiency of kidney was established by hydroxyurea(450 mg?kg-1)and mifepristone(3.75 mg?kg-1).The uterus weight,the amount of embryo and the abortion rate were observed,and the peripheral blood levels of TCR?&T and CD3+T lymphocytes were detected with flow cytometer.【Results】The uterus weight and the amount of embryo were decreased,and the abortion rate was increased in the model group(P
