Effect of Fucoidan on Lipid Metabolism Enzyme in Hyperlipidemia Mice
- VernacularTitle:褐藻糖胶对高脂血症大鼠脂代谢酶的影响
- Author:
Qinghe WU
;
Yanhong XING
;
Ping HUANG
;
Shuwen LI
- Publication Type:Journal Article
- Keywords:
FUCOIDAN/pharmacology;
HYPERLIPIDEMIA/TCD therapy;
HYPERLIPIDEMIA/blood;
LIPID METABOLISM ENZYME;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the effect of fucoidan on lipid metabolism enzyme in hyperlipidemia mice.【Methods】Sixty healthy male SD rats were randomized into 6 groups: normal group,model group,gynostemma pentaphyllum(GP,30 mg/kg) group and low-,moderate-and high-dose fucoidan groups(0.1,0.2 and 0.4 g?kg-1 respectively).Except the normal group,the rats in other groups received high fat emulsion(10 mL?kg-1) by gavage to establish hyperlipidemia models.The activities of lipoprotein lipase(LPL),hepatic lipase(HL) and lecithin cholesterol acyltransferase(LCAT) in different groups were compared.【Results】Serum activities of LPL,HL and LCAT as well as hepatic activities of LPL and HL were increased in low-and moderate-dose fucoidan groups.【Conclusion】Fucoidan decreases the serum triglyceride levels by activating the serum and hepatic LPL and HL activities,and decreases serum cholesterol level by activating hepatic LCAT activity.
