Effect of Modified Sini Powder on nNOS Expression in Hippocampus of Rats with Psychological-Stress-Induced Damage
- VernacularTitle:加味四逆散对心理应激损伤大鼠海马nNOS表达的影响
- Author:
Wenzhu WANG
;
Can YAN
;
Zhiwei XU
;
Lili WU
- Publication Type:Journal Article
- Keywords:
MODIFIED SINI POWDER/pharmacology;
CHRONIC PSYCHOLOGICAL STRESS/TCD therapy;
BRAIN/enzymology;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the effect of Modified Sini Powder(MSP)on the expression of hippocampal neuronal nitric oxide synthase(nNOS)in rats with chronic psychological stress.【Methods】Twenty-four Wistar rats were randomized into 3 groups: normal group,model group(receiving random stress stimulation for 21 days),and MSP group(receiving gastric infusion of MSP 3.38 g for each rat one hour before stimulation).The normal group and the model group received the same volume of saline.The expression of hippocampal nNOS was detected with immunohistochemical method.【Results】nNOS expression was found in neuronal pyramidal cells of hippocampus CA3 area in the three groups.The expression was obvious,positive cell count and its scoring were increased in the model group as compared with the normal group(P
