The role of Cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of breast cancer
- VernacularTitle:COX-2、VEGF-C在乳腺癌中的表达及与淋巴转移的关系
- Author:
Yanchun GAO
- Publication Type:Journal Article
- Keywords:
Breast cancer;
COX-2;
VEGF-C;
Lymphatic metastasis
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of Cyclooxygenase-2(COX-2) and vascular endothelial growth factor-C (VEGF-C) proteins,and their relationship with lymphatic metastasis of breast cancer.Methods: Immunohistochemical staining was used to detect the expression of COX-2 and VEGF-C proteins in 45 cases of breast cancer.The relationship was analyzed between the expression of VEGF-C,COX-2 and age,tumor size,the protein expression of estrogen receptor(ER) and progesterone receptor(PR),clinic phase,axillary lymph node metastasis.Results: The expression rates of COX-2 and VEGF-C in Ⅲ and Ⅳ stages of breast cancer were higher than those ofⅠand Ⅱ stages(P
