Clinical study of the effect of topotecan in combination with chemotherapy on relapsed and refractory acute myelogenous leukemia
- VernacularTitle:拓扑替康联合化疗治疗复发难治性急性髓系白血病的临床探讨
- Author:
Hong HU
- Publication Type:Journal Article
- Keywords:
Leukemia;
Topotecan;
Side effect
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the antileukemic activity and side effects of topotecan in patients with refractory and relapsed acute myelogenous leukemia(AML).Method:12cases of refractory and relapsed AML were treated with topotecan combined with chemotherapy,8 accepted 1 course,and the others accepted 2 courses.Result:4 patients achieved complete remission.3 had partial remission.The total response rate was 58%.The main side effect was myelosuppression.Conclusion:The topotecan-based induction therapy has antileukemic effect in some patients with refractory and relapsed AML.
