Osteogenit growth peptide induces collagen Ⅰ in rat osteoblast-like cells
- VernacularTitle:成骨生长肽对大鼠成骨细胞I型胶原蛋白的影响
- Author:
Bo DING
- Publication Type:Journal Article
- Keywords:
OGP;
Osteoblast;
Collagen I
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To elucidate the effect of osteogenic growth peptide(OGP) on the collagen I in cultured rat osteoblast-like cells.Method:Osteoblast-like cells were treated with 10-11~10-7mol/L of OGP for 7d respectively.Then cells were processed for SABC stain and examination of the collagen I.Microscopy and analysis system was used to investigate the changes of collagen I.Result:OGP can promote the expression of collagen I in rat osteoblast-like cells.The most best concentration of OGP is 10-9mol/L.Conclusion:Our results demonstrate that OGP at 10-9mol/L may stimulate the expression of collagen I in rat osteoblast-like cells in vitro.
