Preparation and performance testing for super-paramagnetic contrast agent of magnetic resonance
- VernacularTitle:超顺磁性氧化铁纳米粒子的制备及性能检测
- Author:
Wei BAI
- Publication Type:Journal Article
- Keywords:
SPIO;
Magnetic resonance imaging;
Contrast agent;
Nanoparticles
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the possibility as antisense gene carriers.Preparation of super paramagnetic iron oxide MR contrast agent Iron oxide nanoparticles and test their physical and Magnetic Properties.Methods:the iron oxide nanoparticles is obtained by means of Co-precipitation method,its structure is analyzed by X-ray powder diffraction method,its size and distribution is measured by transmission electron microscope,and its Susceptibility is measured by Vibrating Sample Magnetometer dollars.Results:Testing after dextran-coated particle diameter overall,the size is20～35nm,core diameter of around is 5nm,These particles possessed some characteristics of super paramagnetic.Relaxation rate Of the sample is 0.155?106/(mol?sec) and quality saturation magnetic intensity is 69.42162emu/g Fe.Conclusion:the sample possessed the advantages of small size,dispersed,super-paramagnetic,so it could be used as an anti-gene carriers.
