Influences on Pharmacokinetics of Hydrochloric Berberine in Rats Administrated Gangtai with 3 Routes
- VernacularTitle:肛泰3种给药途径对大鼠血清盐酸小檗碱浓度的影响
- Author:
Shaowei JIANG
;
Min HUANG
;
Jianqun LIU
- Publication Type:Journal Article
- Keywords:
Gangtai;
administrated routes;
hydrochloric berberine;
pharmacokinetics;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and compare the pharmacokinetics of hydrochloric berberine in rats administrated Gangtai by 3 routes.Method Rats were taken orally or administrated Gangtai by abdomen skin or rectal,and their serum concentrations of hydrochloric berberine at different time(0～30 h)were determined with HPLC method.Results The main pharmacokinetics parameters of hydrochloric berberine by abdomen skin,rectal and oral administration:Cmax was 127.4,269.4,127.9 g/L respectively,Tmax was 1,0.5,0.5 h respectively,AUC0-30 h was 161 1.44,105 5.61,765.88 g/(L?h)respectively.Conclusion The pharmacokinetics parameters of Gangtai in rats provided academic evidence for clinical application of Gangtai.
