Protective Effects of Ginsenosides Rb_1 and Re on Injury of the Neonate Rat Cardiomyocyte Induced by Aconitine Alkaloids
- VernacularTitle:人参皂苷Rb_1和Re对乌头碱所致心肌细胞损伤的保护作用
- Author:
Xi DONG
;
Shiping ZHAO
;
Yan LIU
- Publication Type:Journal Article
- Keywords:
aconitine alkaloids;
ginsenoside Rb1;
ginsenoside Re;
myocard zymogram;
Ca2+ channel
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of ginsenoside Rb1 and Re on injury of the neonate rat cardiomyocyte induced by aconitine alkaloids.Methods The influence of aconitine and ginsenoside Rb1,Re together in neonate rat cardiomyocyte was observed respectively.The influence of these components in neonate rat cardiomyocyte was examined by myocard zymogram.The expression of Ca2+ channel gene Cav1.2 mRNA of neonate rat cardiomyocyte after treatment was observed by RT-PCR.Results The ginsenoside Rb1 and Re were able to decrease the release of AST and LDH,reverse Cav1.2 mRNA abundance induced by aconitine.Conclusion The ginsenoside Rb1 and Re which together with aconitine can alleviate the side effects and boost up the therapeutic effects of aconitine.The action mechanism may be relation with that the ginsenoside Rb1 and Re can decrease injuries of the neonate rat cardiomyocytes and abundant expression of Cav1.2 mRNA induced by aconitine.
