Solubilization of hydropropyl-?-cyclodextrin to paclitaxel and its relative molecular inclusion mechanism
- VernacularTitle:羟丙基-?-环糊精对紫杉醇的增溶作用及其分子包合机制研究
- Author:
Xuenong ZHANG
;
Lihua TANG
;
Xueying YAN
;
Qiang ZHANG
- Publication Type:Journal Article
- Keywords:
paclitaxel;
hydroxypropyl-?-cyclodextrin (HP-?-CD);
inclusion complex
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the solubilitization effect of macromolecular paclitaxel with cyclodextrin and mechanism between inclusion complex and drugs. Methods The influence effects on paclitaxel solubility were studied with ?-cyclodextrin (?-CD) and hydroxypropyl-?-cyclodextrin (HP-?-CD) as inclusion carriers. The chemical shifts of hydrogen atom in host and guest molecules were also investigated with 1H-NMR. Results The form of inclusion complex was responsible by host molecules and the enhancement solubility of paclitaxel in HP-?-CD was larger than that in ?-CD and increased with the ratio increasing. The benzene ring in the molecular of HP-?-CD and paclitaxel showed the most significant effect. Conclusion The solubility of diossolved paclitaxel is improved by hydroxypropyl-?-cyclodextrin.
