Optimized formulation of resveratrol solid lipid nanoparticles by uniform design in combination with central composite design/response surface methodology
- VernacularTitle:均匀设计联用星点设计优化白藜芦醇固体脂质纳米粒制备处方
- Author:
Xinchun WANG
;
Shixiang HOU
;
Wen LI
;
Yawe ZHOU
- Publication Type:Journal Article
- Keywords:
uniform design;
central composite design;
resveratrol;
solid lipid nanaoparticles
- From:
Chinese Traditional Patent Medicine
1992;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To establish a method of optimizing the formulation of resveratrol solid lipid nanoparticles(SLN)quickly and accurately by uniform design in combination with central composite design and response surface.METHODS:Firstly,uniform design was used to optimize the main factors from the five influence factors such as entrapment efficiency,drug loading,average diameter,and PDI(Polydispersity Index).Then,on the ground of it,the main factors determined by unifrom design were optimized by central composite design with three evaluation parameters and response surfaces were nonlineated according to best-fit mathematic models,so optimized formulation was obtained.RESULTS:According to the optimal conditions,the entrapment efficiency,the drug loading,the average diameter and the PDI(Polydispersity Index)of the prepared Res-SLN were 56.77%,2.59%,167 nm and 0.176,respectively.CONCLUSION:The design of combination of uniform design with central composite design is a feasible and convenient method to optimize the prescription of Res-SLN.
