Mechano-chemical Signal Pathway of Endothelial Cells Migration Induced by Fluid Shear Stress
- VernacularTitle:流体剪切应力诱导内皮细胞迁移的力学-化学信号途径
- Author:
Chang YU
;
Yi ZHANG
;
Xiaoheng LIU
- Publication Type:Journal Article
- Keywords:
fluid shear stress;
endothelial cells;
cell migration;
mechanosensor
- From:Space Medicine & Medical Engineering
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The migration of endothelial cell induced by fluid shear stress is related to many physiological and pathological responses in organism.The redistribution of membrane receptors and proteins,caused by shear stress,is a vital step for cell migration,followed by chemical reactions and signal transduction.Then cell morphological changes are induced,such as polarity,protrusion,and adhesion,which lead to the migration of endothelial cell at last.The goal of this paper is to review what is known about the mechanical models of endothelial cell migration and the responses of cells to fluid flow.It is helpful for better understanding the intrinsic mechanism of mechano-chemical signal pathway of the migration of endothelial cells induced by fluid shear stress.
