Influence of intestinal flora dysregulation induced by antibiotic on immunity and toll-like receptor 2,4 gene expression in mice
- VernacularTitle:抗生素诱导小鼠肠道菌群失调对免疫功能和Toll样受体2、4基因表达的影响
- Author:
Chonghai LIU
- Publication Type:Journal Article
- Keywords:
Antibiotic;
Intestinal flora;
Immunity function;
Toll-like receptor
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of intestinal flora dysregulation induced by antibiotic on immune function and toll-like receptor(TLR)2,4.Methods:Sixty BALB/c mice were divided into two groups:antibiotic and control group.The mice in antibiotic group were treated with cefoperazone orally for consecutive 7 days.After 7 days,mice were inoculated with Candida albicans.Results:The quantity of Enterobacteriaceae,Enterococcus,Bifidobacterium and Lactobacillus in antibiotic therapy group was significantly lower than that in the control group.The quantity of Candida albicans increased in the antibiotic therapy group.Spleen index,lymphocytic transformation rate induced by PHA,delayed-type hypersensitivity and the number of antibody secreting cells,the gene expression of TLR2 and TLR4 mRNA in spleen were lower than those in the control group.Conclusions:The intestinal flora dysregulation induced by antibiotic may decrease the immune function and toll-like receptor 2,4 gene expression in mice.
