Pathological changes of the optic nerve in EAE
- VernacularTitle:实验性变态反应性脑脊髓炎大鼠视神经的病理学改变
- Author:
Na XU
- Publication Type:Journal Article
- Keywords:
Encephalomyelifis;
Experimental autoimmune;
Optic Neuritis;
Demyelination
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To dynamically observe the pathological changes of the optic nerve in EAE.Methods:The animal model was established in Wistar rat.The experiment rats were randomly divided into 8,12,18,and 30day groups.The changes of optic nerve were observed using light and electron microscopes.Results:Under light microscope,the optic nerve fibers showed bulb-like degeneration,the axis irregularity swelling,phlegmonosis cell infiltrating,a quantity of glial cell and collagen tissue formed hyperplastic tissue.Under electron microscopy,the axons showed bulb-like degeneration,myelin sheaths were loose,microtubule and microfilament disappeared.Conclusion:Demyelination occurs in the optic nerve of EAE.By establishing the EAE animail model,we can see the pathological changes of the optic nerve in EAE,which can provide evidences for clinical threatment of this disease.
