Progress in the study of drug-eluting intra-stent thrombosis
- VernacularTitle:药物洗脱支架内血栓形成研究进展
- Author:
Zhifu GUO
;
Xing ZHENG
;
Yongwen QIN
- Publication Type:Journal Article
- Keywords:
Drug-eluting stent;
Percutaneous coronary intervention;
Stent thrombosis;
Risk factors
- From:Journal of Interventional Radiology
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Durg-eluting stent has been regarded as the milestone in the history of PCI for their efficiency in the prevention of coronary arterial restenosis after percutaneous coronary intervention. But unfortunately intra-stent thrombosis continues to be a serious complication of contemporary DES use. The incidence of drug-eluting stents thrombosis is at least not lower than that of bare metal stents at present. The clinical consequences of stent thrombosis are frequently catastrophic, including death in 40% to 50% of the cases or major myocardial infarction in 60% to 70%. Premature discontinuation of standard antiplatelet therapy is by far the most important predictor of stent thrombosis with DES and other predictors included renal failure, diabetes, bifurcation lesions, multiple lesions or multivessel disease, long stents, female, advanced age, stent underexpansion and residual stenosis etc. The delayed endothelialization may be the underling mechanism of DES thrombosis.
