Effect of Fuming Tablet on ATP, MDA Content and SOD Activity in Retinal Tissue of Rabbit Retinal Detachment and Reattachment Model
- VernacularTitle:复明片对视网膜脱离复位三磷酸腺苷、丙二醛含量和超氧化物歧化酶活性的影响
- Author:
Zhirong ZHU
;
Qinghua PENG
;
Ji CHEN
- Publication Type:Journal Article
- Keywords:
retinal detachment and reattachment;
Fuming Tablet;
ATP;
MDA;
SOD;
animal model
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Fuming Tablet on the content of ATP and MDA, and the activity of SOD in retinal tissue of rabbit retinal detachment (RD) and reattachment model. Methods 48 rabbits were randomly divided into 4 groups, with 12 in each. 12 rabbits were taken as healthy control and fed with normal saline, the others in model group, western medicine group and Fuming Tablet group were prepared as RD model by injecting Sodium Halyuronate (Helen) into subretinal spaces, and the detached retinas were reattached automatically in 10 ～ 14 days. They were administered with normal saline, mixed preparation of western medicines and Fuming Tablet suspension respectively, then the content of ATP, MDA and SOD activity were determined in postoperative 1 week (the retina remained detached) and 3 weeks (the detached retina reattached). Results Effect of fuming tablet of increasing the content of ATP and the activity of SOD, reducing the content of MDA was similar with that of the mixed preparation of ATP, VitB1 and Venoruton. Conclusion Fuming Tablet can significantly improve the oxidation resistance and depress the lipid peroxidation of retinal tissue, thus alleviate and inhibit the development of retinal pathological changes to some extent.
