Study on the Effect of Aldehydes and Tannic Acid on the Stability of Soft Capsules
- VernacularTitle:醛类及鞣酸对软胶囊稳定性的影响
- Author:
Hanlin XU
;
Chenggang HUANG
;
Zhiming WU
- Publication Type:Journal Article
- Keywords:
formaldehyde;
soft capsules;
disintegration time;
fumaric acid;
tannic acid
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of aldehydes and tannic acid on soft capsules, approach how to prevent soft capsules from delayed disintegration. Methods Add aldehydes and tannic acid to soft capsules material ingredient, to proceed accelerating stability trial and test the disintegration time. Result Little increase of aldehydes amount had great effect on the disintegration time of soft capsules, different aldehydes and tannic acid had different effect on the disintegration time, adding some organic acid such as fumaric acid to the material would improve disintegrating property. Conclusion The amount of aldehydes and tannic acid contained in the material and ingredient should be controlled strictly when prepare soft capsules so that the disintegration time of capsules could be complying with the Pharmacopeia.
