EFFECTS OF MELATONIN ON HPA AXIS IN RATS
- VernacularTitle:褪黑素对SD大鼠下丘脑-垂体-肾上腺皮质的影响
- Author:
Le BU
;
Zhimin LIU
- Publication Type:Journal Article
- Keywords:
Melatonin;
HPA axis;
Ultramicrostructure;
Radioimmunity;
Transmission electron microscopy;
Rat
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the functional and ultramicrostructural effects of melatonin on hypothalamus-pituitary-adrenal(HPA) axis in normal and diabetic rats.Methods By means of radioimmunoassay we observed the effects of three doses of melatonin(0.5mg/kg for low,10mg/kg for medium,50mg/kg for high) and lipoicin on level of CRH,ACTH and COR in normal and diabetic rats' plasma for three weeks respectively.The ultramicrostructural changes of hypophysis and pituitary gland after melatonin treatment were also observed under transmission electron microscope(TEM).Results 1.Compared with control groups,the CRH level of melatonin groups in normal and diabetic rats notably reduced(P
